Correlation between alterations in the "autism gene" and in the expression of RhoA protein to be proven by 2025?

Researchers at the University of California at the San Diego School of Medicine are studying a genomic variant associated with autism spectrum disorder: 16p11.2. Alterations in this specific gene modulate molecular mechanisms that alter the expression of RhoA, a protein that plays a large role in many basic cell functions, such as development and movement.

According to the tests, when this protein was inhibited in models with the genomic variation that was similar to autism, their neuronal migration was restored to the levels seen in the control model, without the genomic variation. That seems to indicate a correlation between alteration in the gene and the expression of RhoA protein. Nonetheless, given that these tests were in vitro, scientists still need more tests in animal and human models before drawing that conclusion.

If by the end of 2024 tests in animals and humans prove the correlation between the manipulation of gene "16p11.2" and the production of the RhoA protein, this market will resolve to “Yes”.

This market will be resolved based on news (with verifiable sources) and scientific studies on the subject from sources or publications that Futuur finds credible and reputable, such as, but not restricted to, World Health Organization, Nature Magazine, Science and other specialized scientific journals.