Will antibodies against the nucleocapsid be considered neutralizing for SARS-CoV-2 by the end of 2020?
Market Rules
One of the things that are keeping scientists awake is discovering how the immunity against the SARS-CoV-2 works, how long it lasts and how many people in a population need to be immune for herd immunity to take place.
A recent study in São Paulo found that more than 30% of infected people develop only a kind of antibody that is not detected with conventional testing: an antibody against the nucleocapsid structure, instead of against the spike protein. They know that people that developed this nucleocapsid antibody against SARS-CoV-1 still have it now, even 17 years later. What they do not know yet is if the nucleocapsid antibody is neutralizing, i.e., can prevent the virus from causing an infection.
If studies confirm, by the end of 2020, that this kind of antibody is neutralizing agains SARS-CoV-2 this market will be resolved as "Yes".